As more and more dermal fillers come to the marketplace, people can be confused about the differences between them. Most fillers have been designed to target specific issues such as volume loss or deep creases. Two popular fillers, Restylane and Perlane are confused because the same company, QMed, makes them both. But they have different purposes.
Both Restylane and Perlane are hyaluronic acid fillers. Hyaluronic acid is a naturally occurring substance in the human body responsible for giving the skin volume, hydration, and fullness. Unfortunately, as we age our hyaluronic acid production decreases, so our skin becomes more lax and prone to wrinkles and folds. Both of these fillers are injected to fill the space between collagen and elastin fibers within the skin to restore lost volume. They also attract and bind to water molecules to hydrate and fill the injection area.
Despite their similarities, Perlane and Restylane are actually complements to one another.
Perlane has a thicker consistency than Restylane. In fact, Perlane is three times thicker than Restylane. Because it is thicker, Perlane would have the potential to be seen in the injection sites, so it needs fat in the area to help hide the filler. Because of this it works well adding volume to the cheeks, chin, and nasolabial folds. Perlane is great for moderate to severe folds.
Restylane is more popular than Perlane, having been injected over 11 milllion times. It is far thinner than Perlane. This allows Restylane to flow and spread out, so it is perfect for defining the lip edge or the hollows under the eyes. It works well on sensitive areas with finer wrinkles and thinner skin.
Duration? Perlane lasts longer because its thickness allows it to stay in the tissue longer. Restylane lasts about a year or more; Perlane six months longer than that.